中药逆转肿瘤获得性耐药机制的研究新进展

张铭予, 李春雨, 李国辉

中国药学杂志 ›› 2018, Vol. 53 ›› Issue (24) : 2069-2073.

PDF(4026 KB)
中国药学杂志
PDF(4026 KB)
中国药学杂志 ›› 2018, Vol. 53 ›› Issue (24) : 2069-2073. DOI: 10.11669/cpj.2018.24.001
综述

中药逆转肿瘤获得性耐药机制的研究新进展

  • 张铭予, 李春雨, 李国辉*
作者信息 +

Recent Progress in Research on Reversing the Mechanism of Tumor Acquired Drug Resistance by Traditional Chinese Medicines

  • ZHANG Ming-yu, LI Chun-yu, LI Guo-hui*
Author information +
文章历史 +

摘要

计算机搜索中国知网(CNKI)、万方数据、Pubmed等数据库。检索词为:中药、中药复方、中药单体、中成药、中药注射液、耐药、多药耐药、肿瘤。收集、整理和分析近5年关于中药单体和中药复方逆转肿瘤耐药机制的研究文献。试图为中药干预肿瘤获得性耐药机制的研究提供思路。中药对肿瘤的化疗耐药干预主要为调节细胞膜表面的转运蛋白表达状况,诱导细胞凋亡,调节细胞中相关酶的表达等。中药单体及其复方制剂能够逆转肿瘤的多药耐药,中药制剂和化疗药物的联合使用可明显增强临床治疗效果,逆转肿瘤耐药。中药可通过多靶点逆转肿瘤获得性耐药,但其明确的逆转机制尚待深入研究。

Abstract

Collect and analyze recent studies on the reversal of the mechanism of tumor drug resistance by traditional Chinese medicines, and provide ideas for research on the intervention of acquired tumor resistance with traditional Chinese medicines. CNKI, Wanfang, Pubmed and other databases were searched for literature on the reversal of the mechanism of tumor drug resistance by traditional Chinese medicines and Chinese herbal compound in the past 5 years. The search terms included ‘traditional Chinese medicine’, ‘traditional Chinese medicine formula’, ‘traditional Chinese medicine monomer’, ‘traditional Chinese medicine patent prescription’, ‘traditional Chinese medicine injection’, ‘drug resistance, multidrug resistance’, and ‘tumor’. The literatures were collated and analyzed. The interventions of traditional Chinese medicine on drug resistance of tumors mainly were regulating the expression of transporter proteins on the cell surface, inducing apoptosis, and regulating the expression of related enzymes in cells. Traditional Chinese medicine monomers and their compound preparations can reverse the multidrug resistance of tumors. The combined use of Chinese medicine preparations and chemotherapeutic drugs can significantly enhance the clinical treatment effect and reverse the drug resistance of tumors. Traditional Chinese medicines can reverse acquired tumor resistance through multiple targets, but the precise reversal mechanism remains to be further studied.

关键词

多药耐药 / 单体 / 中药复方 / 肿瘤治疗

Key words

multidrug resistance / monomer / Chinese herbal compound / tumor therapy

引用本文

EndNote

Ris (Procite)

Bibtex

导出引用
张铭予, 李春雨, 李国辉. 中药逆转肿瘤获得性耐药机制的研究新进展[J]. 中国药学杂志, 2018, 53(24): 2069-2073 https://doi.org/10.11669/cpj.2018.24.001
ZHANG Ming-yu, LI Chun-yu, LI Guo-hui. Recent Progress in Research on Reversing the Mechanism of Tumor Acquired Drug Resistance by Traditional Chinese Medicines[J]. Chinese Pharmaceutical Journal, 2018, 53(24): 2069-2073 https://doi.org/10.11669/cpj.2018.24.001
中图分类号： R969   

参考文献

[1] CHEN W Q, SUN K X, ZHENG R S, et al. Report of cancer incidence and mortality in different areas of China, 2014. China Cancer(中国肿瘤), 2018, 27(1):1-14.
[2] CHEN W Q, ZHENG R S, ZHANG S W, et al. Analysis of cancer incidence and mortality in elderly population in China, 2013. Chin J Oncol(中华肿瘤杂志), 2013, 2017,39(1):60-66.
[3] WANG Y G, LI Q, LI Y J, et al. Current status of traditional Chinese medicine on reversing tumor multi-drug resistance. China J Chin Mater Med(中国中药杂志), 2014,39(24):4693-4698.
[4] GUO Q, CAO H, QI X, et al. Research progress in reversal of tumor multi-drug resistance via natural products. Anticancer Agents Med Chem, 2017,17(11):1466-1476.
[5] CHEN T, SONGX, MA Y Y, et al. The research advance of traditional Chinese medicine to reverse the tumor multidrug resistance. Northwest Pharm J(西北药学杂志), 2014,29(3):324-328.
[6] ZHU B Y, HUANG J, HUANG Y L, et al. Reversal of P-glycoprotein and multidrug resistance in tumors. J China Pharm(中国药房), 2011,22(6):550-552.
[7] XU J F, CHEN Y, ZHENG C P, et al. The correlation between the expression of P-gp、GST-π、Topo-Ⅱ、HER-2 and the efficacy of docetaxel-based combination chemotherapy in patients with breast cancer. Chin J Clin Ration Drug Use(临床合理用药杂志), 2010,3(19):7-9.
[8] SUI H, FAN Z Z, LI Q. Signal transduction pathways and transcriptional mechanisms of ABCB1/Pgp-mediated multiple drug resistance in human cancer cells. J Int Med Res, 2012,40(2):426-435.
[9] WANG C,FANG P F,CAI Y L. Research progress of ABC membrane transporters and their regulation in tumor drug resistance and new mechanism of detoxification. Chin Pharm J(中国药学杂志), 2017,52(22):1961-1965.
[10] NAKANISHI T, ROSS D D. Breast cancer resistance protein (BCRP/ABCG2):its role in multidrug resistance and regulation of its gene expression. Chin J Cancer, 2012, 31(2):73-99.
[11] ZHU M M, LIU B, LI J. Research progress in multidrug resistance-associated protein MRP expression in human hepatocellular carcinoma, the mechanisms of resistance and reversal. J Kunming Med Univ(昆明医学院学报), 2012,33(1B):202-206.
[12] WU Z, LI X, ZHENG Y, et al. In vitro and in vivo inhibition of MRP gene expression and reversal of multidrug resistance by siRNA. Basic Clin Pharmacol Toxicol, 2011, 108(3):177-184.
[13] FOUQUET G,DEBUYSSCHER V, OULED-HADDOU H, et al. Hepatocyte SLAMF3 reduced specifically the multidrugs resistance protein MRP-1 and increases HCC cells sensitization to anti-cancer drugs. Oncotarget,2016,7(22):32493-32503.
[14] SCHEPER R J, HENRICUS J, BROXTERMAN, et al. Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance. Cancer Res, 1993, 53(7):1475-1479.
[15] DONG J, SHA M, ZHANG H F, et al. Therapeutic mechanism of qiyeling granules reversing drug resistance in lung adenocarcinoma cells. Chin J Basic Med Tradit Chin Med(中国中医基础医学杂志), 2014, 20(5):678-682.
[16] HE S H,XUE Z L. Relationship between glutathione S-transferase-π and multidrug resistance of ovarian cancer. J Xinxiang Med Univ(新乡医学院学报), 2017,34(4):320-322,326.
[17] LIU H, YANG Z P, ZANG L Q, et al. Downregulation of glutathione S-transferase A1 suppressed tumor growth and induced cell apoptosis in A549 cell line. Oncol Lett, 2018, 16(1):467-474.
[18] FENG Y, ZHANG H, GAO W, et al. Expression of DNA topoisomerase Ⅱ-alpha: clinical significance in laryngeal carcinoma. Oncol Lett, 2014,8(4):1575-1580.
[19] CHIKAMORI K, HILL J E,GRABOWSKI D R, et al. Downregulation of topoisomerase Ⅱ beta in myeloid leukemia cell lines leads to activation of apoptosis following all-trans retinoic acid-induced differentiation/growth arrest. Leukemia, 2006, 20(10):1809-1818.
[20] ZHANG C, ZHONG Q, ZHANG X F, et al. Enhancement effect of cordycepin on the chemosensitivity of cisplatin on A549 cells by inhibiting the NF-kappa B pathway. Chin Pharm J(中国药学杂志),2015,50(2):147-151.
[21] DANISH L, IMIG D,ALLGOWER F, et al. Bcl-2-mediated control of TRAIL-induced apoptotic response in the non-small lung cancer cell line NCI-H460 is effective at late caspase processing steps. PLoS One, 2018,13(6):e0198203.
[22] GUNALDI M, ISIKSACAN N, KOCOGLU H, et al. The value of serum survivin level in early diagnosis of cancer. J Cancer Res Ther, 2018,14(3):570-573.
[23] YING R B,FENG J, LI J J, et al. Expression of survivin and caspase-3 in gastric cancer and its clinical significance. China Oncol(中国癌症杂志), 2010, 20(1):17-21.
[24] SU S,CHENG X, WINK M. Natural lignans from arctiumlappa modulate P-glycoprotein efflux function in multidrug resistant cancer cells. Phytomedicine, 2015, 22(2):301-307.
[25] XIA Y Z, NI K G,GUO C, et al. Alopecurone B reverses doxorubicin-resistant human osteosarcoma cell line by inhibiting P-glycoprotein and NF-kappa B signaling. Phytomedicine, 2015, 22(3):344-351.
[26] HU T, K W TO KENNETH, WANG L, et al. Reversal of P-glycoprotein (P-gp) mediated multidrug resistance in colon cancer cells by cryptotanshinone and dihydrotanshinone of Salvia miltiorrhiza. Phytomedicine, 2014, 21(11):1264-1272.
[27] LI C,GUAN X,WANG P, et al. Reversal of P-glycoprotein-mediated multidrug resistance is induced by saikosaponin D in breast cancer MCF-7/adriamycin cells. Pathol Res Pract,2017, 213(7):848-853.
[28] JAGADEESHAN S, DAVID D, JISHA S, et al. Solanum nigrum unripe fruit fraction attenuates adriamycin resistance by down-regulating multi-drug resistance protein (Mdr)-1 through Jak-STAT pathway. BMC Complement Altern Med, 2017, 17(1):370.
[29] LI C, SUN B Q, GAI X D. Compounds from Chinese herbal medicines as reversal agents for P-glycoprotein-mediated multidrug resistance in tumours. Clin Transl Oncol, 2014, 16(7):593-598.
[30] YANG X D,WANG X L,YANG W H, et al. Research of reversal effect of PESV to multi-drug resistance of leukemia stem cell. Chin J Chin Mater Med(中国中药杂志), 2016,41(24):4648-4653.
[31] CHEN M C, HSU H H, CHU Y Y, et al. Lupeol alters ER stress-signaling pathway by downregulating ABCG2 expression to induce oxaliplatin-resistant LoVo colorectal cancer cell apoptosis. Environ Toxicol, 2018, 5(33):587-593.
[32] PAN Y, SHAO D, ZHAO Y, et al. Berberine reverses hypoxia-induced chemoresistance in breast cancer through the inhibition of AMPK-HIF-1alpha. Int J Biol Sci, 2017, 13(6):794-803.
[33] ZHANG W J, KOU Y Q, ZHU P J. Research progress of gambogic acid as active ingredient of traditional Chinese medicine (TCM) gambog. Ed Department Chin J Pharm (Online Edition)(中国药剂学杂志网络版), 2013, 11(6):121-129.
[34] HOU Y, ZHU P, CHEN Y Q, et al. Progress in understanding mechanisms behind anti-tumor effects of gambogic acid. World Chin J Digestol(世界华人消化杂志), 2013,21(24):2412-2417.
[35] QIAN J Q, SUN B, FANG Z Z. Reversal effects of piperlongumine on drug resistance of human lung cancer A549/DDP cell to cisplatin. J China Pharm(中国药房), 2014,25(47):4433-4436.
[36] WU C Y, KE Y, ZHANG Y W, et al. Zincpolyanemine from Chinese herbs polyalthia nemoralis extract reverses the chemoresistance to cisplatin in human ovary cancer cells. Med J Wuhan Univ(武汉大学学报 医学版), 2017,38(2):253-257.
[37] WANG Y B, LU Z T, ZHANG Q G, et al. Effect of quercetin on multidrug resistance reversal of lung adenocarcinoma cell line A549 /DDP. J Binzhou Med(滨州医学院学报), 2013,36(2):86-89.
[38] HUANG Y,YOU S M,SHEN Y B. Dihydromyricetin sensitizes drug-resistant melanoma cells to carboplain through the SIRT1/JNK pathway. Chin J Mod Appl Pharm(中国现代应用药学), 2017,34(12):1689-1694.
[39] LI Q, LAI Z, YA N Z, et al. Hedyotisdiffusa willd inhibits proliferation and induces apoptosis of 5-FU resistant colorectal cancer cells by regulating the PI3K/AKT signaling pathway. Mol Med Rep,2018, 17(1):358-365.
[40] SUI H, LIU X, JIN B H, et al. ZuoJin Wan, a traditional Chinese herbal formula, reverses P-gp-mediated MDR in vitro and in vivo. Evid Based Comp Alter Med, 2013:Article ID957078.
[41] LI G Z,DAI Y, HUANG R B, et al. In vitro study on the reversal effect of serum containing Xihuang pill on the multidrug-resistance of hepatic cancer cells via P-glytoprotein pathway. Chin J Integr Tradit Western(中国中西医结合消化杂志),2016,24(2):83-86,91.
[42] FENG F B, ZHUANG J,HAN H E, et al. Research on Chinese compound of reducing phlegm and resolving masses on reversal of multidrug of MCF-7/ADM transplantation tumor in nude mice. Acta Academiae Med Weifang(潍坊医学院学报), 2014, 36(3):211-213.
[43] XU Y, XU Y Q, SHEN M Q. Effects of Jianpi Huatan formula on the metastases of gastric carcinoma and the expressions of Survivin and Bax. World J Integr Tradit West Med(世界中西医结合杂志), 2018,13(1):35-38,43.
[44] GAO Y, WANG Y, CHEN Q, et al. Effect of Buzhong Yiqi Decoction on tumor growth and MRP protein expression in lung adenocarcinoma bearing xenografts in nude mice. Lishizhen Med Mater Med Res(时珍国医国药),2016,27(8):1796-1799.
[45] JINN L, XU M, LUO X H, et al. Stephania tetrandra and ginseng-containing Chinese herbal formulation NSENL reverses cisplatin resistance in lung cancer xenografts. Am J Chin Med, 2017, 45(2):385-401.
[46] ZHANG Y, ZHANG Q, FANG Z, et al. A Chinese herbal formula, chang-wei-qin, synergistically enhances antitumor effect of oxaliplatin. Pathol Oncol Res, 2015, 21(2):389-397.

基金

中国医学科学院医学与健康科技创新工程项目资助(2016-I2M-1-001)
PDF(4026 KB)

Accesses

Citation

Detail
段落导航
相关文章

/

〈 〉